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NEIBank


NAR Molecular Biology Database Collection entry number 1025
Wistow G.1, Peterson K.1, Gao J.1, Buchoff P.1, Hauser M.A.2, Bowes Rickman C.3 and Hoover D.4
1Section on Molecular Structure and Functional Genomics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
Department of 2Medicine and 3Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
4Helix Group, Center for Information Technology, National Institutes of Health, Bethesda MD 20892, USA

Database Description

NEIBank is a project for ocular genomics. This includes both the generation and analysis of new cDNA libraries for human and animal model eye tissues and the creation of a database and web site for eye-related expression data, known eye disease genes and disease loci. Compilations of clustered and identified EST data for NEIBank libraries (and others available through Unigene) are presented by species and tissue and annotated with links to other databases, GO terms and direct links to genome browsers. A library comparison tool allows pair wise comparison of libraries for the same species or for any species in which homologous genes have been identified. Links for ordering clones are provided.

Recent Developments

SAGE data for human eye tissues are now presented through the EyeSAGE database. Both EST and SAGE data can be interrogated in several ways, including gene identifiers, GO terms and chromosomal locations. EyeBrowse, a custom, eye-centric version of the UCSC genome browser presents EST and EyeSAGE data along with known eye disease genes. Data for loci of unidentified eye disease genes can also be displayed along with expression data to assist identification of candidate genes.

References

1. Wistow, G. (2002) A project for ocular bioinformatics: NEIBank. Mol Vis, 8, 161-163.
2. Wistow, G. (2006) The NEIBank project for ocular genomics: data-mining gene expression in human and rodent eye tissues. Prog Retin Eye Res, 25, 43-77.
3. Bowes Rickman, C., Ebright, J.N., Zavodni, Z.J., Yu, L., Wang, T., Daiger, S.P., Wistow, G., Boon, K. and Hauser, M.A. (2006) Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE. Invest Ophthalmol Vis Sci, 47, 2305-2316.


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