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KEGG - Kyoto Encyclopedia of Genes and Genomes

NAR Molecular Biology Database Collection entry number 112
Kanehisa, Minoru; Goto, Susumu; Sato, Yoko; Furumichi, Miho; Tanabe, Mao

Database Description

KEGG (Kyoto Encyclopedia of Genes and Genomes) is an integrated database resource consisting of sixteen main databases, broadly categorized into systems information (PATHWAY, BRITE, MODULE), perturbed systems information (DISEASE, DRUG and ENVIRON), genomic information (ORTHOLOGY, GENOME, GENES and SSDB) and chemical information (COMPOUND, GLYCAN, REACTION, RPAIR, RCLASS and ENZYME). One of the main objectives of KEGG is to establish links from gene catalogs of completely sequenced genomes to higher-level systemic functions of the cell, the organism and the ecosystem. Major efforts have been undertaken to manually create a knowledge base for such systemic functions by capturing and organizing experimental knowledge in computable forms; namely, in the forms of molecular networks called KEGG pathway maps, BRITE functional hierarchies and KEGG modules. Continuous efforts have also been made to develop and improve the cross-species annotation procedure for linking genomes to the molecular networks through the KEGG Orthology (KO) system. Furthermore, knowledge on human diseases, drugs and other health-related substances is now integrated as perturbations of the KEGG molecular networks. KEGG can be used as a reference knowledge base for integration and interpretation of large-scale datasets generated by genome sequencing and other high-throughput experimental technologies. The KEGG databases are daily updated and made freely available at the KEGG website ( and the GenomeNet mirror site (

Subcategory: Metabolic pathways

Go to the abstract in the NAR 2014 Database Issue.
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