NAR Molecular Biology Database Collection entry number 1170
Dou L.1, Wang Y.2, Wu S.1, Wang X.2, Mao Y.2, Li L.2, Tang L.1, Wang X.1, Zhao D.2, He F.1 and Zhu Y.1
1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China 2 Beijing Institute of Health Administration and Medicine Information, Beijing 100850, P. R. China

Database Description

With the rapid progress of HLPP (Human Liver Proteome Project), massive data of liver proteome expression profile has been generated. To manage the valuable resource effectively and present it for researchers with different interest to carry out analysis conveniently, a web-based database of liver proteome expression profile named dbLEP has been developed. The researchers especially interested in large scale proteome or specific protein function could get great benefit from it. Currently dbLEP holds two datasets of human fetal liver and HLPP French liver with approximately 17247 proteins and 36990 peptides. Some other datasets, such as HLPP Chinese liver and subcellula, C57 mouse liver subcellula will be online soon. Both non-redundant proteins and all possible proteins are presented so that users could understand each dataset comprehensively. Besides the complete identification, dbLEP provides related information like mass spectrums for users to verify the confidence. Plenty of protein annotation, such as description of function, family, GO classification etc. and lots of cross links to the other related databases, such as UniPort, Kegg and HPRD etc., are provided as well. Users could get information by browsing each dataset, searching interested proteins with specified accession number, protein name, subcellular localization, or searching in batch mode. Meanwhile, users are enabled to customize their own filter criteria based on unique peptide count, spectrum count etc., and then get the corresponding identification subset with specific confidence. Blast and FTP services are also available. dbLEP is accessible at http://lep.hupo.org.cn and http://dblep.hupo.org.cn.


This work has been supported by the Chinese National Key Program of Basic Research (2006CB910803), the National High Technology Research and Development Program of China (2006AA02A312, 2006AA02Z334), National Natural Science Foundation of China (30621063) and Beijing Municipal Key Research Program (H030230280590).


1. He F. (2005) Human liver proteome project: plan, progress, and perspectives. Mol Cell Proteomics 4(12): 1841-1848.
2.Zhang X, Guo Y, Song Y, Sun W, Yu C, Zhao X, Wang H, Jiang H, Li Y, Qian X, Jiang Y, He F. (2006) Proteomic analysis of individual variation in normal livers of human beings using difference gel electrophoresis. Proteomics 6(19): 5260-5268
3. Song Y, Hao Y, Sun A, Li T, Li W, Guo L, Yan Y, Geng C, Chen N, Zhong F, Wei H, Jiang Y, He F. (2006) Sample preparation project for the subcellular proteome of mouse liver. Proteomics 6(19): 5269-5277.

Go to the abstract in Mol Cell Proteomics
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