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GPCR NaVa database

NAR Molecular Biology Database Collection entry number 1180

Database Description

The GPCR NaVa database describes sequence variants within the family of human G Protein-Coupled Receptors (GPCRs). GPCRs regulate many physiological functions and are the targets for most of today's medicines. The acronym NaVa stands for Natural Variant, which means any (non-artificial) variant that occurs in humans.
The GPCR NaVa database includes:
1) rare mutations (frequency below 1%);
2) polymorphisms (frequency above 1%), including Single Nucleotide Polymorphisms (SNPs);
3) variants without estimates of allele frequency.
The GPCR NaVa database aids GPCR research by categorising and integrating information on variants from databases and scientific papers. Moreover, the GPCR NaVa database is linked with the reputable GPCRDB.


The GPCR NaVa database resulted from a joint project of the Leiden Medicinal Chemistry section of the Leiden/Amsterdam Center for Drug Research (LACDR) and the Leiden Institute of Advanced Computer Science (LIACS). We are very grateful to the Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO) for providing financial support.


Kazius J., Wurdinger K., van Iterson M., Kok J., Back T., and Ijzerman A.P. (2008) GPCR NaVa database: natural variants in human G protein-coupled receptors. Hum Mutat. 29(1), 39-44.

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