NAR Molecular Biology Database Collection entry number 1267

http://centrosome.dacya.ucm.es

Nogales-Cadenas, R.¹, Abascal, F.², Díez-Pérez, J.², Carazo, J.M.², Pascual-Montano, A.¹

¹Computer Architecture Department. Complutense University of Madrid. Spain.²National Center for Biotechnology. CNB-CSIC. Madrid, Spain.

Contact pascual@fis.ucm.es

Active research on the biology of the centrosome during the past decades has allowed the identification and characterization of many centrosomal proteins. Unfortunately, the accumulated data are still dispersed among heterogeneous sources of information. Here we present CentrosomeDB, which intends to compile and integrate information related to the human centrosome. We have compiled a set of 383 likely human centrosomal genes, and recorded the associated supporting evidence. CentrosomeDB offers several perspectives to study the human centrosome, including evolution, function, and structure. The database contains information on orthology relationships with other species, including fungi, nematodes, arthropods, urochordates and vertebrates. Predictions of the domain organization of CentrosomeDB proteins are graphically represented in different sections of the database, including sets of alternative protein isoforms, interacting proteins, groups of orthologs, and the homologs identified with blast. CentrosomeDB also contains information related to function, gene-disease associations, SNPs and the 3D structure of proteins. Apart from important differences in the coverage of the set of centrosomal genes, our database differentiates from other similar initiatives in the way information is treated and analyzed. CentrosomeDB is publicly availablec.

We would like to acknowledge César Vicente and the National Institute for Bioinformatics (INB) for technical support. This work has been partially funded by the Spanish grants S-Gen-0166/2006, BIO2007-67150-C03-02, CSD2006-00023 and TIN2005-5619. FA is a recipient of an I3P contract of the Spanish MEC. APM acknowledges the support of the Spanish Ramón y Cajal program.

Go to the abstract in the NAR 2009 Database Issue.

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