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KinMutBase


NAR Molecular Biology Database Collection entry number 139

Database Description

KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signaling molecules, in which mutations can lead into diseases, including e.g. immunodeficiencies, cancers, and endocrine disorders. The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also ser/thr protein kinases, as well as an update of the tyrosine kinases. There are altogether 251 entries representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in nonhomologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations and changes to restriction enzyme patterns.


Go to the abstract in the NAR 2000 Database Issue.
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