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ExoCarta


NAR Molecular Biology Database Collection entry number 1558
Suresh Mathivanan1, Cassie Patterson2, Gavin E. Reid2 and Richard J. Simpson1
1Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia 2Department of Chemistry, Michigan State University, East Lansing, USA

Database Description

ExoCarta is as a free web-based resource that catalogues proteins and RNA identified in exosomes. ExoCarta is a manually curated database that contains molecular data on unpublished and published exosomal studies. It catalogs information on the exosomal isolation and purification procedures, samples used, investigator details and exosomal molecular components such as proteins, mRNA and miRNA as reported in the scientific literature. ExoCarta can be queried using the gene symbol/name or browsed as a group based on the organism, molecular content type and the sample material. Currently, ExoCarta (Version 4) contains information on 13,333 protein entries, 2,375 mRNA entries and 764 miRNA entries resulting from 146 exosomal studies. We believe that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and initiate new exosomal studies.

Recent Developments

Inclusion of lipid data, data deposition by exosomal researchers

References

1. Pan, B.T. and Johnstone, R.M. (1983) Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell, 33, 967-978.
2. Simpson, R.J., Lim, J.W., Moritz, R.L. and Mathivanan, S. (2009) Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics, 6, 267-283.
3. Johnstone, R.M. (2006) Exosomes biological significance: A concise review. Blood Cells Mol Dis, 36, 315-321.
4. Vidal, M., Mangeat, P. and Hoekstra, D. (1997) Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation. J Cell Sci, 110 (Pt 16), 1867-1877.
5. Raposo, G., Nijman, H.W., Stoorvogel, W., Liejendekker, R., Harding, C.V., Melief, C.J. and Geuze, H.J. (1996) B lymphocytes secrete antigen-presenting vesicles. J Exp Med, 183, 1161-1172.
6. Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P., Raposo, G. and Amigorena, S. (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med, 4, 594-600.
7. Mathivanan, S., Lim, J.W., Tauro, B.J., Ji, H., Moritz, R.L. and Simpson, R.J. (2010) Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol Cell Proteomics, 9, 197-208.
8. Caby, M.P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G. and Bonnerot, C. (2005) Exosomal-like vesicles are present in human blood plasma. Int Immunol, 17, 879-887.
9. Pisitkun, T., Shen, R.F. and Knepper, M.A. (2004) Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A, 101, 13368-13373.
10. Admyre, C., Johansson, S.M., Qazi, K.R., Filen, J.J., Lahesmaa, R., Norman, M., Neve, E.P., Scheynius, A. and Gabrielsson, S. (2007) Exosomes with immune modulatory features are present in human breast milk. J Immunol, 179, 1969-1978.
11. Taylor, D.D., Akyol, S. and Gercel-Taylor, C. (2006) Pregnancy-associated exosomes and their modulation of T cell signaling. J Immunol, 176, 1534-1542.

Category: Cell biology

Go to the abstract in the NAR 2012 Database Issue.
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