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Interferon Stimulated Gene Database


NAR Molecular Biology Database Collection entry number 16
Contact deveerm@ccf.org

Database Description

Interferons (IFN) are a family of multifunctional cytokines that activate transcription of a subset of genes. The gene products induced by IFN are responsible for the antiviral, antiproliferative and immunomodulatory properties of this cytokine. In order to obtain a more comprehensive understanding of the genes regulated by IFNs we have used different microarray formats to identify over 400 interferon stimulated genes (ISG). To facilitate the dissemination of this data we have compiled a database comprising the ISGs assigned into functional categories. The database is fully searchable and contains links to sequence and Unigene information. The database and the array data is accessible via the world wide web at (http://www.lerner.ccf.org/labs/williams/ ). We intend to add published ISG-sequences and those discovered by further transcript profiling to the database to eventually compile a complete list of ISGs.


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