NAR Molecular Biology Database Collection entry number 176
Le Novere, N.
EMBL Outstation - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Contact lenov@ebi.ac.uk

Database Description

Ligand-gated ion channels are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits, and the last two decades revealed an unexpected wealth of genes coding for these subunits. The Ligand Gated Ion Channel database (LGICdb) has been developed to handle this increasing amount of data. The database aims to provide a unique entry for each gene, containing annotated nucleic acid and protein sequences. The entries can be browsed by various criteria, or searched by keywords or sequence similarity. In addition to the sequences, the LGICdb provides phylogenetic analyses and atomic coordinates when available. The database is accessible via the World Wide Web where it is continuously updated. Periodic snapshots are available for download.


1. Le Novere N., Changeux J.-P. (2001). LGICdb: the ligand-gated ion channel database. Nucleic Acids Research 29: 294-295.
2. Le Novere N., Changeux J.-P. (2001). The Ligand Gated Ion Channel database (LGICdb), an example of a sequence database in neuroscience. Phyl. Trans. Roy. Soc., 356: 1121-1130.
3. Le Novere N, Changeux JP (1999). The Ligand Gated Ion Channel database. Nucleic Acids Research 27: 340-342.
4. Le Novere N, Changeux JP (1995). Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. Journal of Molecular Evolution 40 :155-172.

Go to the abstract in the NAR 2006 Database Issue.
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