NAR Molecular Biology Database Collection entry number 1878
Wilson, Robert; McGuire, Christina; Mohun, Timothy, the DMDD project
The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK

Database Description

The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The goal of the project is to identify animal models useful for investigating the basis of human developmental disorders. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. All the image data from the embryos and placenta we have studied and the phenotypes we have observed can be viewed and searched through the DMDD project website.


This research was supported by the Wellcome Trust Strategic Award "Deciphering the Mechanisms of Developmental Disorders (DMDD)", WT100160. In addition, this work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK, the UK Medical Research Council, and the Wellcome Trust.


1. Mohun T., Adams D.J., Baldock R., Bhattacharya S., Copp A.J., Hemberger M., Houart C., Hurles M.E., Robertson E., Smith J.C., et al.
2. Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice. Dis. Model. Mech. 2013;6:562-566. Weninger W.J., Geyer S.H., Martineau A., Galli A., Adams D.J., Wilson R., Mohun T.J. Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy. Dis. Model. Mech. 2014;7:1143-1152.

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