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UniProt


NAR Molecular Biology Database Collection entry number 197
Apweiler R.1, Bairoch A.2 and Wu C.H.3,4
1 EMBL Outstation - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
2Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
3Department of Biochemistry and Molecular Biology, and 4National Biomedical Research Foundation, Georgetown University Medical Center, 3900 Reservoir Road, NW, Box 571414, Washington, DC 20057-1414, USA

Database Description

The UniProt/Swiss-Prot Protein Knowledgebase is a curated protein sequence database established in 1986. It provides a high level of annotation (such as the description of protein function, domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. It is part of the Universal Protein Knowledgebase (UniProt), a "one-stop shop" that allows easy access to all publicly available information of protein sequence annotation.

Acknowledgements

UniProt is mainly supported by the National Institutes of Health (NIH) grant 1 U01 HG02712-01. Minor support for the EBI's involvement in UniProt comes from the two European Union contracts BioBabel (QLRT-2000-00981) and TEMBLOR (QLRI-2001-00015) and from the NIH grant 1R01HGO2273-01. Swiss-Prot activities at the SIB are supported by the Swiss Federal Government through the Federal Office of Education and Science.

References

1. Apweiler, R., Bairoch, A., Wu, C.H., Barker, W.C., Boeckmann, B., Ferro, S., Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M.J., Natale, D.A., O’Donovan, C., Redaschi, N. Yeh, L.L. (2004) UniProt: the Universal Protein knowledgebase. Nucleic Acids Res. 32, D115-D119.
2. Boeckmann, B., Bairoch, A., Apweiler, R., Blatter, M., Estreicher, A., Gasteiger, E., Martin, M.J., Michoud, K., O'Donovan, C., Phan, I., Pilbout, S., Schneider, M. (2003) The Swiss-Prot protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res. 31, 365-370.


Go to the abstract in the NAR 2006 Database Issue.
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