NAR Molecular Biology Database Collection entry number 215
Hulo, N., Sigrist, C.J.A., Langendijk-Genevaux, P., Le Saux, V., Bairoch, A.
Swiss Institute of Bioinformatics, CMU, University of Geneva, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland

Database Description

The PROSITE database ( consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to a documentation that gives useful biological information on the protein family, domain, or functional site identified by the signature.

Recent Developments

The PROSITE web page has been redesigned and several tools have been implemented not only to scan PROSITE but also to identify new signatures. We also introduced the possibility to scan PDB with a PROSITE entry or a user defined pattern and visualize matched positions on 3D structures.


PROSITE is funded by grants from the Swiss federal government.


Hulo N., Sigrist C.J.A., Le Saux V., Langendijk-Genevaux P.S., Bordoli L., Gattiker A., De Castro E., Bucher P., Bairoch A. Recent improvements to the PROSITE database. Nucleic Acids Res. 2004, 32: D134-D137.

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