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ARED


NAR Molecular Biology Database Collection entry number 232
Bakheet, T.1, Williams, B.2, Khabar, K.2
1King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
2Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA

Database Description

The adenylate uridylate-rich elements (AREs) mediate the rapid turnover of mRNAs encoding proteins that regulate cellular growth and body response to exogenuous agents such as microbes,inflammatory and environmental stimuli. The Adenylate Uridylate (AU)-Rich Element Database, ARED-mRNA version 2.0, contains information not present in the previous ARED. This includes additional data entries , new information and links to Unigene, LocusLink, RefSeq records, and mouse homologue data. An ARE consensus sequence specific to the 3¢UTR is the basis of ARED that demonstrated two important findings: (i) AREs are present in a large, previously unrecognized set of human mRNAs; and (ii) ARE-mRNAs encode proteins of diverse functions which are largely involved in early and transient biological responses. In this update, we have modified the strategy for identifying ARE-mRNA in order to systematically deal with inconsistencies of molecule type and mRNA region in GenBank records. Potential uses for the ARED in functional genomics are also given. The database is accessible via the web, http://rc.kfshrc.edu.sa/ared, with a new querying system that allows searching ARE-mRNAs by any public database identifier or name. The ARED website also contains relevant links to uses for the ARED.

Recent Developments

(1) Modified Search Strategy (2) New entries (3) Query engine with multiple identifiers (4) Functional genomics links (uses of ARED)

Acknowledgements

We would like to acknowledge Shazia N. Subani and Bushra Siddiqui for their excellent assistance


Go to the abstract in the NAR 2008 Database Issue.
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