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The tmRNA website


NAR Molecular Biology Database Collection entry number 249

Database Description

tmRNA (also known as 10Sa RNA or SsrA) plays a central role in an unusual process termed trans-translation, whereby a stalled ribosome switches from a problematic mRNA to a short reading frame within tmRNA during translation of a single polypeptide. Research on the mechanism, structure and biology of tmRNA is served by the tmRNA Website, a collection of sequences, secondary structures and other information. Four pseudoknots are usually present in each tmRNA, so the database is rich with information on pseudoknot variability. An interesting variation on tmRNA structure is the two-piece form that results from circular permutation of the gene, which has evolved independently in two separate bacterial lineages. Ongoing genome sequencing projects are diligently monitored, and the database is updated frequently throughout the year.


Go to the abstract in the NAR 2004 Database Issue.
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