NAR Molecular Biology Database Collection entry number 252
Pesole, G.1, Liuni, S.2, Grillo, G.2, Licciulli, F.3, Mignone, F.1, Gissi, C.1, Saccone, C.3
1Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, 20122 Milano, Italy
2Centro di Studio sui Mitocondri e Metabolismo Energetico C.N.R., via Amendola 165/A, 70126 Bari, Italy
3Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, via Orabona 4, 70126 Bari, Italy

Database Description

The 5' and 3' untranslated regions of eukaryotic mRNAs may play a crucial role in the regulation of gene expression controlling mRNA localization, stability and translational efficiency. For this reason we developed UTRdb, a specialized database of 5' and 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs. Furthermore, UTRdb entries have been annotated for the presence of repetitive elements. All internet resources we implemented for retrieval and functional analysis of 5' and 3' untranslated regions of eukaryotic mRNAs are accessible at http ://bighost.area.ba.cnr.it/BIG/UTRHome/

Recent Developments

More regulatory elements are annotated in UTRdb entries and included in UTRsite


This work has been supported by 'Ministero Università e Ricerca Scientifica', Italy (PRIN99, Programma Biotecnologie legge 95/95-MURST 5%; Progetto MURST Cluster C03/2000, CEGBA) and Telethon, Italy

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