NAR Molecular Biology Database Collection entry number 270

http://www.ncbi.nlm.nih.gov/Structure/

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA

Contact bryant@ncbi.nlm.nih.gov

Three-dimensional structures are now known for roughly half of all protein families. It is thus quite likely, in searching sequence databases, that one will encounter a homolog with known structure and be able use this information to infer structure-function properties. The goal of Entrez''s 3D structure database is to make this information accessible and useful to molecular biologists. To this end, Entrez''s search engine provides three powerful features: (1) Links between databases; one may search by term matching in MEDLINE, for example, and link to 3D structures reported in these articles. (2) Sequence and structure neighbors; one may select all sequences similar to one of interest, for example, and link to any known 3D structures. (3) Sequence and structure visualization; identifying a homolog with known structure, one may view a combined molecular-graphic and alignment display, to infer approximate 3D structure. Entrez''s MMDB (Molecular Modeling DataBase) may be accessed at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Structure.

Go to the abstract in the NAR 2007 Database Issue.

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