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ASTD


NAR Molecular Biology Database Collection entry number 28
EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

Database Description

The Alternative Splicing Database (ASD) Project aims to understand the mechanism of alternative splicing on a genome-wide scale by creating a database of alternative splice events and the resultant isoform splice patterns of genes from human, and other model species.

At the moment three databases are available: AltSplice, AltExtron, and AEdb. AltSplice and AltExtron implement a computational pipeline that detects and characterise alternative intron/exons, alternative splice events, and isoform splice patterns. AltExtron considers gene entries from the EMBL database, while AltSplice considers gene entries from EnsEMBL. AEdb is the manually collected & curated (from literature) equivalent. AEdb comes in four forms, namely: AEdb-Sequence (sequence and properties of alternatively splice exons), AEdb-Function (data on functional aspects of alternative splicing), AEdb-motif (data and sequence of known splice regulatory motifs), and AEdb-minigene (a collection of known minigene constructs for alternative splice events).

Other satellite databases generated by the members of the ASD consortium will be posted in due course. Currently, the computationally generated AltSplice database has been integrated with the manually curated database of AEdb. This integration adds the value of evidence to computationally predicted isoform splice events.


Go to the abstract in the NAR 2006 Database Issue.
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