NPD - Nuclear Protein Database

NAR Molecular Biology Database Collection entry number 369
Dellaire, G.1, Farrall, R.2, Bickmore, W.A.2
1Dept. of Cell Biology,The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
2MRC Human Genetics Unit, Crewe Road, Edinburgh, United Kingdom EH4 2XU

Database Description

The NPD is a curated database that contains information on more than 1200 vertebrate proteins that are thought, or are known, to localise to the cell nucleus. Each entry is annotated with information on predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. In addition, information on the sub-nuclear localisation of each protein is provided and the biological and molecular functions are described using Gene Ontology (GO) terms. The database is searchable by keyword, protein name, sub-nuclear compartment and protein domain/motif. Links to other databases are provided (e.g. Entrez, SWISS-PROT, OMIM, PubMed, PubMed Central). Thus, NPD provides a gateway through which the nuclear proteome may be explored. The database can be accessed at and is updated monthly.


We would like to acknowledge the help of MRC HGU computing services and Dr. Heidi Sutherland for comments and data entry during the development of NPD. We especially thank all colleagues who have contributed to the development and information content of NPD. The NPD was made possible by funding from the Medical Research Council (UK) and the James S. McDonnell Foundation. GD was supported by a fellowship from the Canadian Institutes of Health Research (CIHR) and WAB is a Centennial Fellow of the James S. McDonnell Foundation.


Bickmore, WA and HGE Sutherland (2002) Addressing protein localization within the nucleus EMBO J. 21(6):1248-1254.
Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Caceres JF, Bickmore WA. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet. 10(18):1995-2011.
Tate P, Lee M, Tweedie S, Skarnes WC, Bickmore WA. (1998) Capturing novel mouse genes encoding chromosomal and other nuclear proteins. J Cell Sci. 111 (17):2575-85.

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