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SDAP


NAR Molecular Biology Database Collection entry number 372
Ivanciuc, O., Schein, C.H., Braun, W.
Sealy Center for Structural Biology Department of Human Biological Chemistry & Genetics University of Texas Medical Branch 301 University Blvd Galveston, TX 77555-1157

Database Description

SDAP (Structural Database of Allergenic Proteins) is a Web server that provides rapid, cross-referenced assess to the sequences, structures, and IgE epitopes of allergenic proteins. The SDAP core is a series of CGI scripts that process the user queries, interrogate the database, perform various computations related to protein allergenic determinants, and prepare the output HTML pages. The database component of SDAP contains information about the allergen name, source, sequence, structure, IgE epitopes, and literature references, and easy links to the major protein (PDB, SWISS-PROT, PIR, NCBI) and literature (PubMed, MEDLINE) on-line servers. The computational component in SDAP uses an original algorithm based on conserved properties of amino acid side chains to identify regions of known allergens similar to user-supplied peptides or selected from the SDAP database of IgE epitopes. This and other bioinformatics tools can be used to rapidly determine potential cross-reactivities between allergens and to screen novel proteins for the presence of IgE epitopes they may share with known allergens.

Acknowledgements

Financial support from a Research Development Grant of the John Sealy Memorial Endowment Fund for Biomedical Research is gratefully acknowledged.


Go to the abstract in the NAR 2003 Database Issue.
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