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Aptamer Database


NAR Molecular Biology Database Collection entry number 411
Lee J.1, Hesselberth J.2, Meyers L.3, Ellington A.1
11Department ofChemistry and Biochemistry, Institute of Molecular Biology. University of Texas at Austin, Austin, TX 78712
2Department of Genome Sciences, University of Washington, Health Sciences Building K-2222/Box357730, Seattle, WA 98915
3Section of Integrative Biology, 1 Univeristy Station C0930, University of Texas at Austin, Austin, TX 78712, USA

Database Description

Aptamers are DNA or RNA molecules that have been selected from random pools based on theirability to bind ligands such as small organic or inorganic compounds, peptides, proteins, and even entire organisms. Like antibodies, aptamers have high affinity and specificity for their targets, and thus have many potential uses in medicine and technology. The Aptamer Database is a comprehensive, annotated repository for information about aptamers and in vitro selection experiments. It is useful not only as a compendium of the research that has been carried out and the sequences that are known, but as a unique resource for theoretical and evolutionary biologists who wish to explore the distribution and relationships between functional nucleic acids. The database is available via the web at http://aptamer.icmb.utexas.edu.

Acknowledgements

This research is funded by the National Science Foundation's Integrative Graduate Education and Research Traineeship (IGERT) in computational phylogenetics, an Army Research Office grant (MURI #DAAD19-99-1-0207), and a NIH grant (1R01 GM61789-01).


Go to the abstract in the NAR 2004 Database Issue.
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