DomIns - Database of Domain Insertions

NAR Molecular Biology Database Collection entry number 448
Aroul-Selvam R.1 and Sasidharan R.2
1The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
2MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

Database Description

Proteins can be formed by single or multiple domains. The process of recombination at the molecular level has generated a wide variety of multi-domain proteins with specific domain organization to cater to the functional requirements of an organism. The functional and structural costs of inserting a domain into another means that multi-domain proteins are usually formed by covalently linking the N-terminus of one domain to the C-terminus of the preceding domain. While this is true in a large proportion of multi-domain proteins, we find a significant fraction of proteins that are the result of domain insertion. The inserted domain breaks the sequence contiguity of the domain into which it is inserted leading to a novel domain organization. This web resource aims to document domain insertions in known protein structures that are classified in the SCOP database. The web server can be accessed from


We acknowledge financial support from Cambridge Commonwealth Trust and the Medical Research Council, UK.

Subcategory: Protein structure

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