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Enzyme Nomenclature


NAR Molecular Biology Database Collection entry number 459
Gerard P. Moss
Department of Chemistry, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK

Database Description

The Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB) is responsible for the maintenance of the enzyme list first published in 1961 and with the last printed edition in 1992 (1). Since 1992 the list has been updated electronically by use of the web. In parallel with this process all published recommendations by the Committee were also converted to a web readable form. More recent changes to Enzyme Nomenclature and new recommendations have only been prepared for the web and are not available in hard copy.

The Enzyme Nomenclature list is an amplified and updated version of the 1992 edition. It currently contains details of over 3700 enzymes. It was prepared from the last printed edition, Enzyme Nomenclature 1992 (1) which was converted into html with additional data added. In many cases the reaction is given in words and illustrated with a reaction diagram (which may be part of a metabolic pathway). Other names for each enzyme are added and links are provided to other databases (BRENDA, EXPASY, KEGG, WIT, etc) and the CAS registry number provided when known. The references now have titles and link where relevant to the PubMed entry.

Enzymes are classified into six classes -- EC 1 oxidoreductases, EC 2 transferases, EC 3 hydrolases, EC 4 lyases, EC 5 isomersaes and EC 6 ligases. The search facility allows searches of all enzyme entries and each class separately.

Updates with new entries, revisions and corrections are posted on the web at regular intervals for review. After two months any agreed corrections or changes are made and the enties are incorporated into the main list.

Acknowledgements

The work by past and present members of the biochemical nomenclature committees NC-IUBMB and JCBN who have contributed to this work over the years is acknowledged.

References

1. IUBMB (1992), Enzyme Nomenclature 1992, Academic Press, San Diego.


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