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HIV Drug Resistance Database


NAR Molecular Biology Database Collection entry number 497
Urvi Parikh, Brendan A. Larder, John W. Mellors, Raymond F Schinazi, Charles E. Calef
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Contact ccalef@lanl.gov

Database Description

The HIV Drug Resistance Database is a compilation of mutations in HIV genes that confer resistance to anti-HIV drugs. Currently, 673 mutations to RT, Protease, Env, Gag, Integrase, FIV RT and SIV RT are stored. The database may be searched by gene, compound, drug class, amino acid position, and other fields; there is a browse facility as well. The Antiviral Drug Resistance Analysis program (http://www.hiv.lanl.gov/content/hiv-db/ADRA/adra.html), available on the site, analyzes user-submitted nucleotide sequences for mutations known to confer drug resistance and links to the records in the database. There is also a program that allows plotting of selected mutations onto a 3-D structure of Protease or RT. The database is published annually as "Mutations in Retroviral Genes Associated with Drug Resistance" in the HIV Sequence Compendium, http://www.hiv.lanl.gov/content/hiv-db/REVIEWS/reviews.html.

Subcategory: Viral genome databases
Subcategory: Drugs and drug design

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