IntAct
NAR Molecular Biology Database Collection entry number 507
Hermjakob, H. 1, Montecchi-Palazzi, L. 2, Lewington, C. 1, Mudali, S. 1, Kerrien, S. 1, Orchard, S. 1, Khadake, J. 1, Harwood, J. 1, Roechert, B. 3, Fierro-Monti, I. 4, Matthiesen, R. 4, Dimmer, E. 1, Lee, V. 1, Robbe, K. 1, Vingron, M. 5, Roepstorff, P. 4, Valencia, A. 6, Margalit, H. 7, Armstrong, J. 8, Bairoch, A. 3, Cesareni, G. 2, Sherman, D. 9, Apweiler, R. 1
1EMBL Outstation - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
2Universita Tor Vergata, Rome, Italy
3Swiss Institute for Bioinformatics, Geneva, Switzerland
4University of Southern Denmark, Odense, Denmark
5Max Planck Institute for Molecular Genetics, Berlin, Germany
6National Center of Biotechnology, Madrid, Spain
7The Hebrew University of Jerusalem, Israel
8Glaxo Research and Development Limited, Stevenage, UK
9University of Bordeaux, France
2Universita Tor Vergata, Rome, Italy
3Swiss Institute for Bioinformatics, Geneva, Switzerland
4University of Southern Denmark, Odense, Denmark
5Max Planck Institute for Molecular Genetics, Berlin, Germany
6National Center of Biotechnology, Madrid, Spain
7The Hebrew University of Jerusalem, Israel
8Glaxo Research and Development Limited, Stevenage, UK
9University of Bordeaux, France
Contact hhe@ebi.ac.uk
Database Description
IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotation or InterPro domains of the interacting proteins. A web service allows direct computational access to retrieve interaction networks in XML format. IntAct currently contains >65.000 binary and complex interactions imported from the literature and curated in collaboration with the Swiss-Prot team, making intensive use of controlled vocabularies to ensure data consistency. All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact.
Recent Developments
IntAct has grown in size from 50.000 to > 65.000 interactions over the last year. The scope has been extended from protein interactions to molecular interactions, including nucleic acid and ligand interactions.
The web interface has been completely rewritten, providing much clearer layout and improved responsiveness. An advanced search facility has been added, enabling ontology-based searches. The documentation has been extended, both an API documentation and animated usage demonstrations have been added. To provide maximum transparency, the curation manual is now publicly available.
Acknowledgements
The IntAct project is funded by the TEMBLOR grant (QLRI-CT-2001-00015) of the European Commission under the RTD programme 'Quality of Life and Management of Living Resources’.
References
Hermjakob, H., Montecchi-Palazzi, L., Lewington, C., Mudali, S., Kerrien, S., Orchard, S., Vingron, M., Roechert, B., Roepstorff, P., Valencia, A., Margalit, H., Armstrong, J., Bairoch, A., Cesareni, G., Sherman, D., Apweiler, R. (2004) IntAct: an open source molecular interaction database. Nucleic Acids Research 32(1), D452-D455.
Category: Metabolic and Signaling Pathways
Subcategory: Protein-protein interactions
Go to the abstract in the NAR 2007 Database Issue.
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