NAR Molecular Biology Database Collection entry number 508
Alcántara R.1, Ast V.1, Axelsen K.B.2, Darsow M.1, de Matos P.1, Ennis M.1, Morgat A.2,3 and Degtyarenko K.1
1EMBL Outstation - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
2Swiss Institute of Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland
3INRIA Rhône-Alpes, Grenoble, France

Database Description

The Integrated relational Enzyme database, IntEnz, is the official version of the Enzyme Nomenclature [1]. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions [2]. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. IntEnz is released monthly. All data in IntEnz is freely available at

Recent Developments

ENZYME: the ENZYME database [3] has been completely integrated into IntEnz. Starting from June 2006, the ENZYME.dat file is generated as a flat file version of IntEnz. ENZYME is available at

IntEnzXML: an XML format for exporting IntEnz data, containing the three views of data (IntEnz, ENZYME and NC-IUBMB), has been developed. Since IntEnz release 24 (31 July 2006), the complete database in IntEnzXML is available at The separate entries in IntEnzXML format also can be downloaded from the corresponding web page.

Cross-references to UniProtKB/Swiss-Prot (, PROSITE (, OMIM (, EC?PDB ( and Catalytic Site Atlas ( were added.


The IntEnz project is supported by the European Commission under FELICS, contract number 021902 (RII3).


1. Fleischmann, A., Darsow, M., Degtyarenko, K., Fleischmann, W., Boyce, S., Axelsen, K.B., Bairoch, A., Schomburg, D., Tipton, K.F., Apweiler, R. (2004) IntEnz, the integrated relational enzyme database. Nucleic Acids Res 32(1), D434-D437.
2. IUBMB (1992) Enzyme Nomenclature: Recommendations (1992) of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. Academic Press, San Diego, CA.
3. Bairoch, A. (2000) The ENZYME database in 2000. Nucleic Acids Res 28(1), 304-305.

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