NAR Molecular Biology Database Collection entry number 605
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA

Database Description

The availability of an increasing number of fully sequenced genomes is opening up many new avenues for comparative genomics. HomoloGene is a system for automatically arranging genes into putative homology groups. The starting gene sets are derived from the gene annotation of over a dozen sequenced eukaryotic genomes. The overall process of grouping genes is guided by an evolutionary tree. Starting with the most closely related groups of organisms, DNA-based alignment measures are used together with conserved gene order to identify clear-cut paralogs and othologs. Following this, protein-based similarity measures are used to identify ancient relationships and extended gene families. Interactive access is provided through the NCBI’s Entrez system. HomoloGene views provide sequence alignments and conserved protein domain structure. In addition, ancillary information is included, where available, thereby providing links to the phenotypic information and the published literature.

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