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AGRIS - Arabidopsis Gene Regulatory Information Server


NAR Molecular Biology Database Collection entry number 618
Davuluri RV1, Sun H1, Palaniswamy SK1, Matthews N2, Molina C2, Grotewold E2
>1Division of Human Cancer Genetics, Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH 43210
2Department of Plant Cellular and Molecular Biology, and Plant Biotechnology Center, The Ohio State University, Columbus, OH 43210

Database Description

AGRIS is an information resource of Arabidopsis promoter sequences, transcription factors and their target genes. AGRIS currently contains two databases, AtTFDB (Arabidopsis thaliana transcription factor database) and AtcisDB (Arabidopsis thaliana cis-regulatory database). AtTFDB contains information on approximately 1,500 transcription factors identified through motif searches and grouped into families, based on the presence of conserved domains. AtTFDB links the sequence of the transcription factors with available mutants and, when known, with the possible genes they may regulate. AtcisDB consists of the 5' regulatory sequences of all 29,388 annotated genes with a description of the corresponding cis-regulatory elements. Users can search the databases for (i) promoter sequences, (ii) a transcription factor, (iii) a direct target gene for a specific transcription factor, or (vi) a regulatory network that consists of transcription factors and their target genes.

Recent Developments

Since the original description of AtcisDB (Davuluri et al, 2003), we have incorporated experimentally described cis-regulatory elements that represent binding sites for several Arabidopsis transcription factors and motifs that are over-represented in genes controlled by particular biotic or abiotic stress conditions.

References

1. Davuluri RV, Sun H, Palaniswamy SK, Matthews N, Molina C, Kurtz M, Grotewold E. AGRIS: Arabidopsis Gene Regulatory Information Server, an information resource of Arabidopsis cis-regulatory elements and transcription factors. BMC Bioinformatics 2003 4(1): 25. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12820902

Category: Plant databases
Subcategory: Arabidopsis thaliana

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