NAR Molecular Biology Database Collection entry number 629
Warfinge R.E., Chalk A.M. and Sonnhammer E.L.L.
Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vÄg 35, S-171 77 Stockholm, Sweden.

Database Description

The siRNA database provides a gene-centric view of human siRNA experimental data, including siRNAs of known efficacy and siRNAs predicted to be of high efficacy by siSearch. Linked to these sequences is information including siRNA thermodynamic properties and the potential for sequence specific off-target effects. The database provides the user with sufficient data to evaluate the siRNAs potential inhibition and sequence-specific off target effects.

In release 1.0 there are 405 experimentally verified siRNAs targeting 50 genes, an average of 8 siRNAs/gene. It contains records and siRNA predictions for all genes in the REFSEQ curated human sequence set (20,410 "NM" sequences and 6767 "XM" sequences). The database is available at


This work was supported by a grant from Pfizer Inc.

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