NAR Molecular Biology Database Collection entry number 750

http://phage.bioc.tulane.edu

Nolan J.M.

Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA

Contact jnolan@tulane.edu

The T4-like bacteriophage genome database is a compilation of information resources for T4-like Bacteriophage Genomes. Both unpublished and GenBank data are included. At present 9 completed genomes are available. Sequences originate both from the Tulane T4-like Sequencing project and from data submitted by outside researchers.

Interactive browsing of completed phage genomes is available using the program. The browser allows users to scan the genome for particular features and to download sequence information plus analyses of those features. Views of the genome are generated showing named genes, BLAST similarities to other phages, predicted tRNAs, and other sequence features. Links are provided from the browser to gene-specific pages, with DNA sequence, protein sequence, protein statistics, interactive sequence alignment to orthologs, hydropathy plots and Pfam protein domain matches.

A T4-like phage BLAST server is available to allow researchers to rapidly search a focused set of genomes. Links to additional phage information are also available, including Genetic Map figures, electron micrographs, annotation tables, sequence files, and links to GenBank annotations. Links to other web sites with information about T4-like bacteriophage are also listed.

Four additional genomes will be available by the end of September 2004. Six additional genomes are presently being sequenced locally and additional genomes may be provided by other researchers.

We are grateful to Jim Karam, and Vasiliy Petrov, from the Department of Biochemistry at Tulane University Health Sciences Center and Henry Krisch, and Claire Bertrand at CNRS, Toulouse, France for their collaboration and to Lincoln Stein for the Browser software. This work was supported by a grant from the National Science Foundation (EF-0333130) to Jim Karam.

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