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Homophila


NAR Molecular Biology Database Collection entry number 8
Gribskov, M.1,2, Bier, E.2, Reiter, L.T.2, Chien, S.1,2
1San Diego Supercomputer Center, University of California, San Diego 9500 Gilman Dr. La Jolla CA 92093-0537
2Department of Biology, University of California, San Diego, 9500 Gilman Dr., La Jolla CA 92093-0349

Database Description

Although many human genes have been associated with disease phenotypes, knowing the mutations in one or several disease genes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate human genetic disease. Homophila is an intergenomic resource linking the human and fly genomes in order to provide a tool for planning functional genomic investigations in Drosophila that address questions about genetic disease in humans. Homophila is a relational database that allows searching based on human disease descriptions, fly phenotypes, human or fly gene names and sequence similarity. Homophila provides a comprehensive linkage between the disease genes compiled in Online Mendelian Inheritance in Man and the complete Drosophila genomic sequence. Homophila is available at http://homophila.sdsc.edu.

Acknowledgements

This work supported in part by the National Institutes of Health through grant through a National Center for Research Resources program grant (P 41 RR08605-06) to the National Biomedical Computation Resource at the San Diego Supercomputer Center.

References

Reiter, LT; Potocki, L; Chien, S; Gribskov, M; Bier, E. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. GENOME RESEARCH, 2001, 11:1114-1125.


Go to the abstract in the NAR 2002 Database Issue.
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