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ChimerDB


NAR Molecular Biology Database Collection entry number 803
Kim N.1, Kim P.1, Nam S.1, Shin S.2 and Lee S.1
1Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea
2School of Chemistry, Seoul National University, Seoul 151-747, Korea

Database Description

ChimerDB is a database of fusion sequences encompassing bioinformatics analysis of mRNA and EST sequences in the GenBank, manual collection of literature data and integration with other well known databases. Fusion transcripts with nonoverlapping alignments at multiple genomic loci were identified and filtered to remove cloning artifacts in cDNA library preparation. Fusion transcripts are classified into two groups - genuine chromosome translocation and fusion between neighboring genes owing to intergenic splicing. Literature data from pubmed abstracts and the fusion data from public resources (OMIM, Sanger CGP, Atlas chromosomes in cancer, and the Mitelman's breakpoint) are integrated to enhance the coverage and reliability. Currently, ChimerDB contains 1,258 fusion cases that involve 1,777 genes, 381 mRNA and 654 EST sequences. It can be accessed at http://genome.ewha.ac.kr/ChimerDB/.

Subcategory: Cancer gene databases

Go to the abstract in the NAR 2006 Database Issue.
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