NAR Molecular Biology Database Collection entry number 814
Zamyatnin A.A, Borchikov A.S., Vladimirov M.G. and Voronina O.L.
A.N.Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of nearly 6000 oligopeptides have been identified from more than 1000 organisms representing all the biological kingdoms. We have compiled the known physical, chemical, and biological properties of these oligopeptides - whether synthesized on ribosomes or by non-ribosomal enzymes - and have constructed an internet-accessible database, EROP-Moscow (Endogenous Regulatory OligoPeptides). This database enables users to perform rapid searches via many key features of the oligopeptides, and to carry out statistical analysis of all the available information. The database lists only those oligopeptides whose chemical structures have been completely determined (directly. or by translation from nucleotide sequences). It provides extensive links with the SwissProt-TrEMBL peptide-protein database, as well as with the PubMed biomedical bibliographic database. EROP-Moscow also contains data on many oligopeptides that are absent from other convenient databases, and is designed for extended use in classifying new natural oligopeptides and for production of novel peptide pharmaceuticals.
This work has been supported by Grant 02-07-90175 from the Russian Foundation for Basic Research (RFBR) and by the Program "Molecular and Cellular Biology", RAS-10P (Russian Academy of Sciences).
Category: Protein sequence databases
Subcategory: Databases of individual protein families
Category: Human and other Vertebrate Genomes
Subcategory: Human ORFs
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