NAR Molecular Biology Database Collection entry number 831
Mokrejs M.1,2, Vopalensky V.1, Kolenaty O.1, Masek T.1, Feketova Z.1, Sekyrova P.3, Skaloudova B.1, Kriz V.4 and Pospisek M.1,5
1Charles University, Faculty of Science, Department of Genetics and Microbiology, Vinicna 5, Prague 2, 128 44, Czech Republic
2Bioinformatics, Donovalska 1658, Prague 4, 149 00, Czech Republic
3University of South Bohemia, Faculty of Biological Sciences, Department of Molecular Biology, Branisovska 31, Ceske Budejovice 370 05, Czech Republic
4Technical University of Liberec, Faculty of Mechatronics and Interdisciplinary Engineering Studies, Department of Software Engineering, Halkova 6, Liberec 461 17, Czech Republic
5Charles University, 2nd Faculty of Medicine, Clinic of Paediatric Haematology and Oncology, V Uvalu 84, Prague 5, 150 06, Czech Republic

Database Description

IRESite is a searchable collection of data concerning the Internal Ribosome Entry Segments (IRES) both of viral and cellular origin. IRESs are the RNA regions which are mostly defined functionally by their ability to attract a eukaryotic ribosomal translation initiation complex independently of presence of the commonly utilized 5'-terminal 7mG cap structure and thus to promote translation initiation even at the internal part of the RNA molecule.

IRESite can provide a broad set of information referring to particular IRES - briefly: primary sequence data, functional data, RNA structure and possible ribosomal RNA complementarity data, RNA:protein interaction data, links to primary databases, information about the relevant experiments and more. Most of the data are not available in the primary databases and are manually extracted from literature sources by IRESite curators. New data can also be submitted through the publicly available IRESite web interface after creating a personal account, however their release needs the curators' approval.

Brief graphical overview of the database is present at


Funding was provided by the Czech Science Foundation (Grant No. 204/03/1487), by Charles University (Grant No. 251/2004/B-BIO/PrF) and by the Czech Ministry of Education (Grant No. MSM 0021620813).

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