NAR Molecular Biology Database Collection entry number 845
Wu T.1,3, Wang J.1,3, Liu C.2,3, Zhang Y.1,3, Shi B.1,3, Zhu X.1,3, Zhang Z.1,3, SkogerbØ G.1, Chen L.2,3, Lu H.2,3, Zhao Y.2 and Chen R.1,2
1Bioinformatics Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2Bioinformatics Research Group, Key Laboratory of Intelligent Information Processing, Institute of Computing Technology, Beijing 100080, China
3Graduate School of the Chinese Academy of Sciences, Beijing, China

Database Description

The Noncoding RNAs and Protein related biomacromolecules Interaction database (NPInter; or is a database that documents experimentally determined functional interactions between noncoding RNAs (ncRNAs) and protein related biomacromolecules (proteins, mRNAs or genomic DNAs). NPInter intends to provide the scientific community with a comprehensive and integrated tool for efficient browsing and extraction of information on interactions between ncRNAs and protein related biomacromolecules (PRMs). Beyond cataloguing details of these interactions, the NPInter will be useful for understanding ncRNA function, as it adds a very important functional element – noncoding RNAs - to the biomolecule interaction network and sets up a bridge between the coding and the noncoding kingdoms.

By functional interactions we mean both physical interactions between an ncRNA and a protein, and other forms of interaction where the combination of an ncRNA and an mRNA or a genomic DNA sequence elicits a cellular reaction. Although biological knowledge on this sort of interactions is contained in the scientific literature, retrieving it will be much easier with the NPInter database.

The database now contains 700 published functional interactions from six model organisms - Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus and Homo sapiens. The amount of data is not large, but the NPInter covers almost all experimentally verified functional interactions between ncRNA and PRM published before the end of the year 2004.

Go to the article in the NAR Database issue.
Oxford University Press is not responsible for the content of external internet sites