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PHI-base


NAR Molecular Biology Database Collection entry number 852
Winnenburg R.1, Baldwin T.K.2, Urban M.2, Rawlings C.1, Köhler J.1 and Hammond-Kosack K.E.2
1 Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, AL5 2JQ, UK
2 Wheat Pathogenesis Programme, Plant-Pathogen Interactions Division, Rothamsted Research, Harpenden, AL5 2JQ, UK

Database Description

To utilise effectively the growing number of verified genes that mediate an organism’s ability to cause disease and / or to trigger host responses, we have developed PHI-base. This is a web-accessible database that currently catalogues 405 experimentally verified pathogenicity, virulence and effector genes from 54 fungal and Oomycete pathogens, of which 176 are from animal pathogens, 227 from plant pathogens and 3 from pathogens with a fungal host. PHI-base is the first on-line resource devoted to the identification and presentation of information on fungal and Oomycete pathogenicity genes and their host interactions. As such, PHI-base is a valuable resource for the discovery of candidate targets in medically and agronomically important fungal and Oomycete pathogens for intervention with synthetic chemistries and natural products. Each entry in PHI-base is curated by domain experts and supported by strong experimental evidence (gene / transcript disruption experiments) as well as literature references in which the experiments are described. Each gene in PHI-base is presented with its nucleotide and deduced amino acid sequence as well as a detailed description of predicted protein’s function during the host infection process. To facilitate data interoperability, we have annotated genes using controlled vocabularies (Gene Ontology terms, EC Numbers, etc.), and provide links to other external data sources (for example, NCBI taxonomy and EMBL). We welcome new data for inclusion in PHI-base, which is freely accessed at: www4.rothamsted.bbsrc.ac.uk/phibase/.


Go to the abstract in the NAR 2008 Database Issue.
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