NAR Molecular Biology Database Collection entry number 882

http://kulibin.mit.edu/coc/

Donald J.E.¹, Hubner I.A.¹, Rotemberg V.M.¹, Shakhnovich E.I.¹ and Mirny L.A.²

¹Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138
²Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-343, Cambridge, MA 02139

Contact jdonald@fas.harvard.edu

The Conservatism of Conservatism (CoC) database presents statistical analysis of the conservation of residue positions in folds across protein families. Residues with high CoC are conserved in families of homologous proteins that acquire the same fold. Such residues can be different in non-homologous proteins (analogues) that exhibit the same fold, but the common conservation points to the general importance of the residue positions. We calculate and present the statistical significance of such conservation and highlight residues that are more conserved than expected given the residue's solvent accessibility. Such high CoC residues have been shown to be crucial for the kinetics and/or thermodynamics of protein folding, are involved in folding nucleation, and are often identified in positions of functional importance such as "super-sites". More information is available at the website (http://kulibin.mit.edu/coc/).

Go to the abstract in Bioinformatics, 2005, 21, 2539-2540

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