NAR Molecular Biology Database Collection entry number 899
Sigrist C.J.A.1, Bairoch A.1,2, Bulliard V.1, De Castro E.1, Langendijk-Genevaux P.S.1 and Hulo N.1
1Swiss Institute of Bioinformatics (SIB), 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland.
2Structural Biology and Bioinformatics Department, CMU, University of Geneva, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland

Database Description

The ProRule database is a new section of PROSITE, which contains additional information about profiles. ProRule provides position specific-information about functionally and structurally relevant residues found in PROSITE profiles, as well as specific information in the Swiss-Prot format using standardized nomenclature and controlled vocabularies. The combination of the high sensitivity and full-length coverage of profiles with the position-specific information, like the one derived from patterns, should help in function determination and, together with the specific information, in the annotation of the UniProt Swiss-Prot knowledgebase by making it more homogeneous and consistent.

Recent Developments

The current version of PROSITE (19.14, of 08 November 2005) contains 561 profiles associated with 478 ProRules, which are currently used for the annotation of Swiss-Prot entries. 125 (~25%) of these rules contain information about functionally and/or structurally important amino acids or subregions which can be accessed through the ScanProsite web page. The complete set of rules will be made publicly available under the PROSITE copyright conditions in the next PROSITE release.


ProRule is supported by grant no. 3152A0-103922/1 from the Swiss National Science Foundation


Sigrist C.J.A., De Castro E., Langendijk-Genevaux P.S., Le Saux V., Bairoch A., Hulo N. (2005) ProRule: a new database containing functional and structural information on PROSITE profiles. Bioinformatics 21: 4060-4066.

Go to the abstract in Bioinformatics, 2005, 21, 4060-4066
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