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DroSpeGe


NAR Molecular Biology Database Collection entry number 924
Gilbert D.G.
Genome Informatics Lab., Department of Biology, Indiana University, Bloomington, IN 47405, USA

Database Description

The Drosophila species comparative genome database DroSpeGe (URL: http://insects.eugenes.org/DroSpeGe/) provides genome researchers with rapid, usable access to twelve new and old Drosophila genomes, since its inception in 2004. Scientists can use, with minimal computing expertise, the wealth of new genome information for developing new insights into insect evolution. New genome assemblies provided by several sequencing centers have been annotated with known model organism gene homologies and gene predictions to provided basic comparative data. TeraGrid supplies the shared cyberinfrastructure for the primary computations. This genome database includes homologies to D. melanogaster and eight other eukaryote model genomes, and gene predictions from several groups. BLAST searches of the newest assemblies are integrated with genome maps. GBrowse maps provide detailed views of cross-species aligned genomes. BioMart provides for data mining of annotations and sequences. Common chromosome maps identify major synteny among species. Potential gain and loss of genes is suggested by Gene Ontology groupings for genes of the new species. Summaries of essential genome statistics include sizes, genes found and predicted, homology among genomes, phylogenetic trees of species, and comparisons of several gene predictions for sensitivity and specificity in finding new and known genes.

Acknowledgements

This project is supported in part by grants from the National Human Genome Research Institute of the National Institutes of Health, and from Sun Microsystems, to D. Gilbert. National Science Foundation TeraGrid access grant provided computing resources.


Go to the abstract in the NAR 2007 Database Issue.
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