NAR Molecular Biology Database Collection entry number 927
Hiller M.1, Nikolajewa S.2, Huse K.3, Szafranski K.3, Rosenstiel P.4, Schuster S.2, Backofen R.1 and Platzer M.3
1 Institute of Computer Science, Bioinformatics group, Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee 106, 79110 Freiburg, Germany
2 Department of Bioinformatics, Friedrich-Schiller-University Jena, Ernst-Abbe-Platz 2, 07743 Jena, Germany
3 Genome Analysis, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstr. 11, 07745 Jena, Germany
4 Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany

Database Description

TassDB (TAndem Splice Site DataBase) stores extensive data about alternative splice events at GYNGYN donors and NAGNAG acceptors. These splice events are of subtle nature since they mostly result in the insertion/deletion of a single amino acid or the substitution of one amino acid by two others. Currently, TassDB contains 114,554 tandem splice sites of eight species, 5,209 of which have EST/mRNA evidence for alternative splicing. In addition, human SNPs that affect NAGNAG acceptors are annotated. The database provides a user-friendly interface to search for specific genes or for genes containing tandem splice sites with specific features as well as the possibility to download large datasets. The aim of this database is to facilitate experimental studies and large-scale bioinformatics analyses of tandem splice sites.


1. Hiller M, S Nikolajewa, K Huse, K Szafranski, P Rosenstiel, S Schuster, R Backofen & M Platzer (2007) TassDB: a database of alternative tandem splice sites. Nucleic Acids Res 35 (Database issue) D188-92.

2. Sinha R, Lenser T, Jahn N, Gausmann U, Friedel S, Szafranski K, Huse K, Rosenstiel P, Hampe J, Schuster S, Hiller M, Backofen R, Platzer M (2010) TassDB2 - A comprehensive database of subtle alternative splicing events BMC Bioinformatics 2010, 11:216

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