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DroID - Drosophila Interactions Database


NAR Molecular Biology Database Collection entry number 928
Yu J, Pacifico S., Guest G., Parrish J.R., and Finley R.L., Jr.
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA

Database Description

DroID, the Drosophila Interactions Database, assembles gene and protein interaction data from a variety of sources into one easily accessible, comprehensive database. The database includes published and unpublished low and high throughput data sets, genetic interactions, and computationally predicted interactions. The predicted interactions are generated based on interactions found in other organisms. The database can be searched using gene and protein information available from Flybase. DroID also includes gene expression data that can be used to filter interaction data. DroID can be accessed through a standard web page or by using IM Browser, a program for exploring multiple data sets and for graphically mapping the interactions. Use of the IM Browser requires no downloads and minimal user configuration or training, thereby enabling rapid initial access to interaction data. All of the data in DroID can be freely downloaded in a variety of formats compatible with analysis tools. The database and IM Browser are accessible from http://www.droidb.org.

Recent Developments

Data from other public databases has been incorporated and new computational predictions have been added. A semi-automated update regime has been instituted to ensure the latest data availability. A new web interface enables rapid searches with results linked to IM Browser for drawing interaction maps. New IM Browser features include filtering on gene expression data and the ability to load a local set of interactions. A new Cytoscape plug-in is also available for accessing DroID.

Acknowledgements

This work was supported by NIH grant HG001536, and the National Center for Proteome and Pathway Mapping, NIH grant P41 RR18327.

References

1. Pacifico S, Liu G, Guest S, Parrish JR, Fotouhi F, Finley RL Jr. (2006) A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics 7:195.


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