NAR Molecular Biology Database Collection entry number 946
Igarashi Y., Eroshkin A., Gramatikova S., Gramatikoff K., Ying Z., Smith J.W., Osterman, A.L. and Godzik, A.
Burnham Institute for Medical Research, La Jolla, California 92037, USA
CutDB is one of the first systematic efforts to build an easily accessible collection of documented proteolytic events for natural proteins in vivo or in vitro. A CutDB entry is defined by a unique combination of these three attributes: protease, protein substrate, and cleavage site. Currently, CutDB integrates 3,070 proteolytic events for 470 different proteases captured from public archives (such as MEROPS and HPRD) and publications. CutDB supports various types of data searches and displays, including clickable network diagrams. Most importantly, CutDB is a community annotation resource based on a Wikipedia approach, providing a convenient user interface to input new data online. A recent contribution of 568 proteolytic events by several experts in the field of matrix metallopeptidases suggests that this approach will significantly accelerate the development of CutDB content. CutDB is publicly available at http://cutdb.burnham.org.
Category: Metabolic and Signaling Pathways
Subcategory: Protein-protein interactions
Category: Proteomics Resources
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