MiST - Microbial Signal Transduction database

NAR Molecular Biology Database Collection entry number 959
Ulrich L.E.1,3 and Zhulin I.B.1,2,3
1Joint Institute for Computational Sciences and 2Graduate School of Genome Science and Technology, The University of Tennessee - Oak Ridge National Laboratory, Oak Ridge, TN 37831-6173, USA
3Center for Bioinformatics and Computational Biology, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332-0230, USA

Database Description

Signal transduction systems link environmental stimuli with adaptive cellular responses and enable an organism to survive and adapt to changing conditions. This communication network of signaling pathways regulates critical cellular activities in all organisms from bacteria to humans. The MiST (Microbial Signal Transduction) database is a comprehensive catalog of the signal transduction proteins (two- and one-component systems) within completely sequenced bacterial and archaeal genomes. These are identified with various domain profiles that directly or indirectly implicate a particular protein as participating in signal transduction. MiST currently contains information on the signal transduction proteins within more than 365 genomes and newly, available genomes are added on a monthly basis. We have designed a user-friendly interface to facilitate the comparison and analysis of bacterial signal transduction repertoires.


We thank the BLAST/STIM research community for many valuable discussions and suggestions on the MiST scope and development. We are grateful to Jan Lukens and "Friends of the Zhulin lab" for their contribution toward our Linux cluster. This work was supported in part by a grant GM072285 from the National Institutes of Health to I.B.Z. and funds provided by the UT-ORNL Joint Institute for Computational Sciences.


Ulrich, LE and Zhulin, IB. (2007) MiST - Microbial Signal Transduction Database. Nucleic Acids Research. 35: in press.

Go to the abstract in the NAR 2007 Database Issue.
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