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Comparasite


NAR Molecular Biology Database Collection entry number 983
Watanabe J.1, Wakaguri H.2, Sasaki M.2, Suzuki Y.2 and Sugano S.2
1Department of Parasitology, Institute of Medical Science, and 2Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1, Shirokanedai, Minatoku, Tokyo 108-8639, JAPAN

Database Description

Comparasite is a database for comparative studies of transcriptomes of parasites, which are defined by the full-length cDNAs from various apicomplexan parasites. It integrates seven individual databases consisting of numerous full-length cDNA clones that we have produced and sequenced: 12 484 cDNA sequences from Plasmodium.falciparum, 11 262 from P. yoelii, 9 633 from P. vivax; 1 518 from P. berghei, 7 400 from Toxoplasma gondii, 5 921 from Cryptosporidium parvum, and 10 966 from the tapeworm Echinococcus multilocularis. Putatively counterpart gene groups are clustered and comparative analysis of any combination of six apicomplexa species is implemented, such as interspecies comparisons regarding protein motifs (InterPro), predicted subcellular localization signals (PSORT), transmembrane regions (SOSUI), or upstream promoter elements. By specifying keywords and other search conditions, Comparasite retrieves putative counterpart gene groups containing a given feature in common or in a species-specific manner. By enabling multi-faceted comparative analyses of genes of apicomplexa protozoa, monophyletic organisms that have evolved to diversify to parasitize various hosts by adopting complex life cycles, Comparasite should help elucidate the mechanism behind parasitism. Our full-length cDNA databases and Comparasite are accessible from http://fullmal.hgc.jp/comp_index.html.


Go to the abstract in the NAR 2007 Database Issue.
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