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IVDB - Influenza Virus Database


NAR Molecular Biology Database Collection entry number 993
Chang S.1,2, Zhang J.1, Liao X.1, Zhu X.1,3, Wang D.1, Zhu J.1, Feng T.1, Yang H.1, Yu J.1 and Wang J.1
1Beijing Institute of Genomics, Chinese Academy of Sciences, B-6 Airport Industrial Zone, Beijing 101300, China
2Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China
3James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou 310007, China

Database Description

Frequent outbreaks of highly pathogenic avian influenza and the increasing data available for comparative analysis require a central database specialized in influenza viruses. We have established the Influenza Virus Database (IVDB) to integrate information and create an analysis platform for genetic, genomic, and phylogenetic studies of the virus. IVDB hosts complete genome sequences of influenza A virus generated by Beijing Institute of Genomics and curates all other published influenza virus sequences after expert annotation. Our Q-Filter system classifies and ranks all nucleotide sequences into 7 categories according to sequence content and integrity. IVDB provides a series of tools and viewers for comparative analysis of the viral genomes, genes, genetic polymorphisms and phylogenetic relationships. A search system has been developed for users to retrieve a combination of different data types by setting search options. To facilitate analysis of global viral transmission and evolution, the IV Sequence Distribution Tool (IVDT) has been developed to display the worldwide geographic distribution of chosen viral genotypes and to couple genomic data with epidemiological data. The BLAST, multiple sequence alignment and phylogenetic analysis tools were integrated for online data analysis. Furthermore, IVDB offers instant access to pre-computed alignments and polymorphisms of influenza virus genes and proteins, and presents the results as SNP distribution plots and minor allele distributions.

Acknowledgements

The work was sponsored by an institutional grant from the Beijing Institute of Genomics, Chinese Academy of Sciences. GFG is supported by National Basic Research Program 973 (Grant No. 2005CB523001) from Ministry of Science and Technology, China. We are indebted to all our collaborators, IV sample providers and other IV sequence producers for their contribution and kind support to the IVDB database. Funding to pay the Open Access publication charges for this article was provided by an institutional grant from the Beijing Institute of Genomics, CAS.

Subcategory: Viral genome databases

Go to the abstract in the NAR 2007 Database Issue.
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