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Nicotine binding to receptor linked to breast cancer cell growth

24 August 2010

When nicotine binds to the nicotinic acetylcholine receptor (nAchR), it is known to promote smoking addiction and may also directly promote the development of breast cancer, according to a study published online 23 August in The Journal of the National Cancer Institute.

While smoking is a well-known risk factor for cancer, non-nicotine components of tobacco have generally been thought to be the carcinogens, so little is known about how nicotine acts on cells to promote cancer cell growth. For breast cancer in particular, some large epidemiological studies have shown that smoking is related to increased breast cancer risk, but they have not been accompanied by molecular biology studies on how that actually works.

Read the free abstract online here.

Read the free editorial here.

Published in the Journal of the National Cancer Institute, Advance Access, 23 August 2010.

Read the full press release here.

For more information and contacts: JNCI press room

In the news

Telegraph - Nicotine in cigarettes linked to breast cancer

Mail Online - Nicotine in cigarettes linked to breast cancer for the first time