Rheumatology podcast
Rheumatology now provides free podcast interviews with experts in the field, keeping you up to date with the latest research on your computer or on the go.
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Psoriatic arthritis and a placebo controlled RCT- April 2012
Methotrexate in psoriatic arthritis - does it really work or are we just giving a placebo? Listen to Professor Robert Moots and Dr Robert Thompson, University of Liverpool discuss the management psoriatic arthritis and analyse a major new randomized placebo-controlled trial of MTX in PsA article recently published by G Kingsley et al. Will this change your practice?
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Psoriatic arthritis and a placebo controlled RCT
Click on the following link to read the related paper for free:
A randomized placebo-controlled trial of MTX in PsA
ANCA-associated vasculitis- March 2012
Professor Robert Moots and Dr Alfred Mahr discuss the challenges of ANCA-associated vasculitis, use of cyclophosphamide and granulomotosis with angiitis. They also discuss the use of rituximab particularly in light of the recommendations published by Guerry et al., how strong is the evidence base for these recommendations and how do these recommendations differ from Dr Mahr’s practice?
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Click on the following link to read the related paper for free:
Recommendations for the use of rituximab in anti-neutrophil cytoplasm antibody-associated vasculitis
BSR and BHPR guidelines on the use of rituximab – Feb 2012
How do you manage refractory rheumatoid arthritis? Listen to Professor Robert Moots, Editor, and Professor Paul Peter Tak from the University of Amsterdam, discuss advances in the treatment of RA and consider differences between clinical trials and real life clinical work. They also debate important new guidelines for the use of the rituximab in rheumatoid arthritis published in the Journal.
What is your view on this? Listen to the Podcast, look up the paper and make up your own mind.
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Click on the following link to read the related paper for free:
BSR and BHPR guidelines on the use of rituximab in rheumatoid arthritis
Inflammatory myopathies - June 2011
Professor Robert Moots and Dr Piet van Riel discuss the treatment of inflammatory myopathies and their efficacies in patients. They talk about a paper, on which Dr van Riel is a co-author, investigating the use of rituximab to treat refractory inflammatory myopathies. They look into the reasons behind the study and give advice for people looking after patients with inflammatory myopathies.
To listen to the podcast click below:
Inflammatory myopathies
Click on the following link to read the related paper for free:
Rituximab treatment in patients with refractory inflammatory myopathies
Early Rheumatoid Arthritis treatment strategies - June 2011
Professor Robert Moots and Professor Janet Pope talk about treatment strategies for early rheumatoid arthritis and the influence cost-effectiveness has. To further highlight the issues they discuss a paper by Schipper et al. comparing the cost-effectiveness of 3 different treatment strategies for patients with early RA.
To listen to the podcast click below:
Treatment strategies
Click on the following link to read the related paper for free:
Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective
Patient perceptions - June 2011
Professor Robert Moots talks to Dr Fernando Cavalcanti about inflammatory arthritis and its treatment in Brazil, highlighting cultural differences in disease management and between patient and Doctor perceptions. They also discuss a review by Verschueren and Westhovens on the challenges of putting scientific treatment into clinical practice.
To listen to the podcast click below:
Patient perceptions
Click on the following link to read the related paper for free:
Optimal care for early RA patients: the challenge of translating scientific data into clinical practice
Cohorts in rheumatoid arthritis – May 2011
Professor Robert Moots and Professor Nancy Lane discuss a paper by Liao et al. about a rheumatoid arthritis cohort in Boston, USA. They talk about the use and importance of such cohorts and how they can inform treatment strategies and practices. They look into the strengths, limitations and challenges for linking bed-side observations to laboratory developments.
To listen to the podcast click below:
Rheumatoid arthritis cohorts
Click on the following link to read the related paper for free:
Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort study
50th Anniversary: A perspective on the past - March 2011
As part of the Journal’s 50th Anniversary celebrations Professor Robert Moots talks to Professor David GI Scott and Dr Michael Snaith about how the rheumatology field has changed over the past 60 years. They discuss treatment, therapeutic and practice developments and how a greater understanding of musculoskeletal disease has shaped these advancements.
To listen to the podcast click below:
A perspective on the past
To find out more information regarding the Journal’s 50th celebrations please click here.
Registries - January 2011
Professor Robert Moots and Professor David Isenberg discuss registries, what they are, their aims and outcomes. They highlight the British Society for Rheumatology Biologics Register, the largest biologics register in the world, detailing its design, aims and findings. Professor David Isenberg has been a guest Editor on the Journal’s themed issue on registries, a collection of papers on this topic.
To listen to the podcast click below:
Registries
To read the Journal’s themed issue on Registries in Rheumatological and Musculoskeletal Conditions please click here.
Is rheumatoid arthritis a genetically distinct subset? – September 2010
Is rheumatoid arthritis a single disease or a group of related diseases? Professor Robert Moots and Professor Anthony Russell discuss this issue, probing into a paper by Ohmura et al. published in Rheumatology. They discuss the key developments of this paper, what it means for treatment and its potential limitations.
To listen to the podcast click below:
Is rheumatoid arthritis a genetically distinct subset?
Click on the following link to read the related paper for free:
Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.
Factors predictive of thrombotic events in SLE patients - August 2010
The Editor Professor Robert Moots and Professor Mohammed Tikly, who is from the University of the Witwatersrand in South Africa, discuss a paper by Burgos et al. about the complications of thrombic events in systemic lupus and the implications of this for clinical practice.
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Factors predictive of thrombotic events in SLE patients
Click on the following link to read the related paper for free:
Factors predictive of thrombotic events in LUMINA, a multi-ethnic cohort of SLE patients.
Spondyloarthropathies: Ankylosing spondylitis with and without concomitant psoriasis - July 2010
In this podcast Professor Robert Moots and Dr Dirk Elewaut discuss spondyloarthropathy diseases and their manifestations. They then go on to discuss a paper by Bruan et al. recently published in Rheumatology on the clinical manifestations of ankylosing spondylitis with and without concomitant psoriasis. They discuss the key issues the paper investigates and the study’s limitations.
To listen to the podcast click below:
Spondyloarthropathies: Ankylosing spondylitis with and without concomitant psoriasis - July 2010
Click on the following link to read the related paper for free:
Clinical manifestations and responsiveness to adalimumab are similar in patients with ankylosing spondylitis with and without concomitant psoriasis
Increase in ferritin levels and interstitial lung disease in dermatomyositis - May 2010
Can measurement of serum ferritin predict the development and severity of acute interstitial lung disease in dematomyositis? Professors Moots and Panayi delve into the paper by Gono et al who propose that the acute phase protein, ferritin, may represent a biomarker for complications in dermatomyositis. To listen to their discussion about this study, issues the paper addressed and its limitations, please click link below.
Increase in ferritin levels and interstitial lung disease in dermatomyositis
Click on the following link to read the related paper for free:
Increased ferritin predicts development and severity of acute interstitial lung disease as a complication of dermatomyositis
Cost of using TNF-alpha inhibitors - April 2010
What is the cost–utility of different treatment strategies after the failure of tumour necrosis factor inhibitor in rheumatoid arthritis?. This paper, set in Finland, by Hallinen et al. is discussed by Professor Robert Moots and Dr. Ronald Frits van Vollenhoven. In the Podcast, they discuss current use of biologics, the effectiveness of TNF inhibitors, DMARDs and rituximab and consider whether the economic model used in this paper can effectively determine relative cost-effectiveness in a clinical setting.
Click on the link below to listen to this interview:
Cost of using TNF-alpha inhibitors
Click on the following link to read the related paper for free:
What is the cost–utility of different treatment strategies after the failure of tumour necrosis factor inhibitor in rheumatoid arthritis?
Cardiovascular disease and rheumatoid arthritis: what is the link? - March 2010
An MRI study about understanding the phenotypes of myocardial involvement in the presence of self-limiting and sustained systemic inflammation by Puntmann et al. is the paper for the discussion between Professor Robert Moots and Dr Christopher Edwards. Is there a link between cardiovascular diseases and RA, how does this association affect patients with RA and questions about this study are answered in this podcast.
Click on the link below to listen to this interview:
Cardiovascular disease and rheumatoid arthritis: what is the link?
Click on the following link to read the related paper for free:
An MRI study about understanding the phenotypes of myocardial involvement in the presence of self-limiting and sustained systemic inflammation
Hypermobility in children - February 2010
A randomized comparative trial of generalized vs targeted physiotherapy in the management of childhood hypermobility by Sue et al. published in Rheumatology is discussed by Robert Moots and Michael Beresford. What is childhood hypermobility and how does it present? Answers to these questions and discussions about the trial form the basis for this podcast.
Click on the link below to listen to this interview:
Hypermobility in children
Click on the following link to read the related paper for free:
A randomized comparative trial of generalized vs targeted physiotherapy in the management of childhood hypermobility
The role of biomarkers in the treatment of rheumatoid arthritis - January 2010
Robert Moots and Stephen Hall discuss the challenges in identifying biomarkers for selecting treatment and predicting adverse events in rheumatoid arthritis. They then discuss a paper by Quartuccio et al. investigating the utility of rheumatoid factor, anti-CCP antibodies and response to TNFi as potential predictors of response to rituximab in rheumatoid arthritis.
Click on the link below to listen to this interview:
The role of biomarkers in the treatment of rheumatoid arthritis
Click on the following link to read the related paper for free:
Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis
Rheumatoid arthritis in elderly patients – December 2009
Is rheumatoid arthritis a homogeneous disease and can it be categorized by age? In our next podcast, Robert Moots with Daniel Solomon discusses not only these questions but also a study recently published by Rheumatology by Marcus Köller et al about the response of methotrexate or TNF inhibitors in elderly patients.
Click on the link below to listen to this interview:
Rheumatoid arthritis in elderly patients
Click on the following link to read the related paper for free:
Response of elderly patients with rheumatoid arthritis to methotrexate or TNF inhibitors compared with younger patients
Active rheumatoid arthritis - (November 2009)
In this podcast, Robert Moots and Roy Fleischmann discuss aspects of rheumatoid arthritis and concerns that patients commonly have about the disease. They then discuss a paper published in the Journal by Aslam Anis et al. about the COMET study that examined the effect of etanercept on work productivity in patients with active rheumatoid arthritis.
Click on the link below to listen to this interview:
Active rheumatoid arthritis
Click on the following link to read the related paper for free:
The effect of etanercept on work productivity in patients with early active rheumatoid arthritis: results from the COMET study
Systemic Sclerosis - July 2009
Pulmonary complications of systemic sclerosis are amongst the most challenging to manage. In this podcast, Ulf Mueller-Ladner discusses the current management of these complications with Robert Moots and the potential for a new, more effective therapy using rituximab - in an article (Daoussis et al) recently published in Rheumatology
Click on the link below to listen to this interview:
Systemic Sclerosis
Click on the following link to read the related paper for free:
Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study
Antiphospholipid Antibody Syndrome - June 2009
In this first podcast from Rheumatology, Munther Khamashta (St Thomas’ Hospital London) and Anisur Rahman (University College London) discuss aspects of treatment of antiphospholipid antibody syndrome (APS) today and the potential for future therapy, in the context of recent advances in understanding the pathological processes that underlie this disease.
The papers discussed in this podcast are available to read for free here:
1. Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies (Mecacci et al)
2. Primary antiphospholipid syndrome: a low-grade auto-inflammatory disease? (Ames et al)
Click on the link below to listen to this interview:
Antiphospholipid Antibody Syndrome
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