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Past Spotlight / Review Focus Issues

Cardiovascular Research regularly publishes 'Spotlight Issues'. These issues are devoted to a specific research topic and contain a number of invited expert reviews.

In addition, a major part of each issue is reserved for original research papers. Please find a full list below of Spotlight Issues published in Cardiovascular Research since 2003, many of which are available free online. Topics covered range from myocardial proteases, to the genetics of arrhythmias, to sodium and its effects on the heart.

"Review Focus issues" consist of a series of reviews that may or may not be accompanied by original papers – they are generally not as broad in scope as Spotlight Issues.

The following list provides links to the introductory editorial of each issue as well as to the issue's table of contents.

Spotlight Issue on: Pregnancy-mediated Heart & Vascular Disease
Published 15 March 2014

Denise Hilfiker-Kleiner, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Zolt Arany, Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA

Click here to access the table of contents for this issue.

Spotlight Issue on: Biomechanical factors in cardiovascular disease
Published 15 July 2013

Paul C. Evans, Department of Cardiovascular Science, University of Sheffield, UK
Brenda R. Kwak, Department of Pathology and Immunology, and Department of Internal Medicine, University of Geneva, Switzerland

Click here to access the table of contents for this issue.

Spotlight Issue on: T-tubules and Ryanodine Receptor Microdomain Signalling in Cardiac Hypertrophy and Failure
Published 1 May 2013

Karin R. Sipido, Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Belgium
Heping Cheng, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking University, Beijing, China

Click here to access the table of contents for this issue.

Review Focus: on Cardiovascular Systems Biology
Published 15 March 2013

Manuel Mayr, King's British Heart Foundation Centre, King's College London

Click here to access the table of contents for this issue.

Spotlight Issue on: Landmark Papers in Cardiovascular Research
Published 1 November 2012

Hans Michael Piper, Heinrich Heine University, Geb. 16.11, Universitatsstrasse, Dusseldorf, Germany
David Garcia-Dorado, Laboratory of Experimental Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Spain

Click here to access the table of contents for this issue.

Spotlight Issue on: Smooth Muscle Cells and Vascular Diseases
Published 15 July 2012

Jean-Baptiste Michel, Denis Diderot University, Paris ,France
Zhenlin Li, Université Paris 06, France
Patrick Lacolley, Université de Lorraine, France

Click here to access the table of contents for this issue.

Spotlight Issue on: Reducing the Impact of Myocardial Ischaemia/Reperfusion Injury
Published: 1 May 2012

Hans Michael Piper, Heinrich Heine University, Geb. 16.11, Universitatsstrasse, Dusseldorf, Germany
David Garcia-Dorado, Laboratory of Experimental Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Spain

Click here to access the table of contents for this issue.



Review focus on the role of microRNA in cardiovascular biology and disease
Published: 15 March 2012

Thomas Thum, Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany
Manuel Mayr, Cardiovascular Division, King's College London School of Medicine, London, UK

Click here to access the table of contents for this issue.


Contemporary cardiogenesis: new insights into heart development
Published: 15 July 2011

Diego Franco , Department of Experimental Biology, Cardiovascular Development Group, University of Jaen, Spain
Robert G. Kelly, Institute of Developmental Biology of Marseilles-Luminy, Université de la Méditerranée, Marseille, France

Click here to access the table of contents for this issue.


Review focus on epigenetics and the histone code in vascular biology
Published: 1 June 2011

Seppo Yla-Herttuala, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
Christopher K. Glass,Department of Cellular & Molecular Medicine, University of California, San Diego, CA USA

Click here to access the table of contents for this issue.


Spotlight on metabolic remodelling in heart failure
Published: 1 May 2011

Torsten Doenst, Department of Cardiothoracic Surgery, University of Jena, Germany
E. Dale Abel, Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA

Click here to access the table of contents for this issue.


New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications
Published: 10 January 2011

Dobromir Dobrev, Division of Experimental Cardiology, Medical Faculty Mannheim, University of Heidelberg, Germany
Stanley Nattel, Department of Medicine and Research Center, Montreal Heart Institute and Université de Montreal, Canada

Click here to access the table of contents for this issue.


Review focus on inorganic nitrite and nitrate in cardiovascular health and disease
Published: 15 February 2011

Christopher G. Kevil, Department of Pathology, LSU Health Sciences Center-Shreveport, USA
David J. Lefer, Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, USA

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Mitochondrial metabolism revisited: a route to cardioprotection
Published: 1 October and 1 November 2010

Derek J. Hausenloy, The Hatter Cardiovascular Institute, University College London, UK
Marisol Ruiz-Meana, Institut de Recerca, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain

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Spotlight on microvascular permeability
Published: 15 June 2010

Fitz-Roy E. Curry, Department of Physiology and Membrane Biology, School of Medicine, University of California, USA
Thomas Noll, Physiologisches Institut, Justus-Liebig-Universität Giessen, Germany

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Spotlight on mechanisms of vascular inflammation
Published: 1 May 2010

Francisco Sanchez-Madrid, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
William C. Sessa, Yale University School, New Haven, USA

Click here to access the table of contents for this issue.


The role of the ubiquitin-proteasome pathway in cardiovascular disease
Published: 15 January 2010

Christophe Depre, Cardiovascular Research Institute, New Jersey Medical School, USA
Saul R. Powell, The Feinstein Institute for Medical Research, Manhasset, USA
Xuejun Wang, Sanford School of Medicine of the University of South Dakota, USA.

Click here to access the table of contents for this issue.


Cardiac protection takes off
Published: 15 July 2009

Hans Michael Piper, Institute of Physiology, Justus Liebig University, Germany
David Garcia-Dorado, Hospital Universitari Vall d’Hebron, Barcelona, Spain

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Lipid signalling in cardiovascular pathophysiology
Published: 1 May 2009

Joel S. Karliner, University of California, San Francisco
Joan Heller Brown, University of California, San Diego

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A translational approach to myocardial remodelling
Published: 15 February 2009

Javier Díez, University of Navarra, School of Medicine, Avda
Georg Ertl, Medizinische Klinik und Poliklinik I, Universita tsklinikum Wurzburg


Click here to access the table of contents for this issue.


Signalling in Cardiac Metabolism
Published: 15 Jul 2008

Gary D. Lopaschuk, University of Alberta, Edmonton
Daniel P. Kelly, Washington University School of Medicine, St Louis

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Mechanisms of Angiogenesis and Remodeling of the Microvasculature
Published: 1 May 2008

Alain Tedgui, Université Paris 7 Hôpital Lariboisière, Paris
Bernard Lévy, Université Paris 7 Hôpital Lariboisière, Paris
Jean-Sébastien Silvestre, Université Paris 7 Hôpital Lariboisière, Paris

Click here to access the table of contents for this issue.


Sarcoplasmic Reticulum and Mitochondria in Cardiac Pathophysiology
Published: 15 Jan 2008

David A. Eisner, University of Manchester, Manchester
David García-Dorado, Institut de Recerca, Barcelona
Hans Michael Piper, Justus Liebig University of Giessen, Giessen

Click here to access the table of contents for this issue.


New Roles of Nitric Oxide in Cardiovascular Signaling
Published: 15 Jul 2007

Santiago Lamas, Centro de Investigaciones Biológicas, Madrid
Charles J. Lowenstein, The Johns Hopkins University School of Medicine, Baltimore
Thomas Michel, Harvard Medical School, Boston

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The TGF β Superfamily in Cardiovascular Biology
Published: 1 May 2007

Jawahar L. Mehta, University of Arkansas, Arkansas
Håvard Attramadal, Rikshospitalet University Hospital, Oslo

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Role of Nutrition in Mechanisms of Cardiovascular Disease
Published: 15 Jan 2007

Louis J. Ignarro, University of California, Los Angeles
William C. Stanley, Case Western Reserve University, Cleveland
Claudio Napoli, II University of Naples, Naples

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Reactive Oxygen Species as Cardiovascular Signaling Molecules
Published: 15 Jul 2006

Ajay Shah, King's College London School of Medicine, London
Heinrich Sauer, University of Giessen, Giessen

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Cardiac Protection by Pre- and Postconditioning
Published: 1 May 2006

Jakob Vinten-Johansen, Emory University School of Medicine, Atlanta
David García-Dorado, Laboratorio de Cardiología Experimental, Servicio de Cardiología, Barcelona
Hans Michael Piper, Justus Liebig University of Giessen, Giessen

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Matrix Metalloproteinases in the Cardiovascular System
Published: 15 Feb 2006

Andrew C. Newby, Bristol Royal Infirmary, Bristol
Francis G. Spinale, Medical University of South Carolina, Charleston
Matthias Pauschinger, Charité-Medizinische Einrichtungen, Berlin

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The Molecular Genetics of Arrhythmias
Published: 15 Aug 2005

Arthur A.M.Wilde, Academic Medical Center, Amsterdam
Connie R. Bezzina, Academic Medical Center, Amsterdam
Dan M. Roden, Oates Institute for Experimental Therapeutics and Division of Clinical Pharmacology, Vanderbilt

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Cardiovascular Aging
Published: 1 May 2005

Salvatore Pepe, Monash University, Melbourne
Edward G. Lakatta, National Institutes of Health, Gerontology Research Center, Baltimore
Matthias Barton, University Hospital, Zürich

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Growth Factors in the Vascular System
Published: 15 Feb 2005

Mark J. Post, University of Maastricht, Maastricht
Johannes Waltenberger, University Hospital of Maastricht, Maastricht

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Signaling Networks in Cardiac Hypertrophy
Published: 15 Aug 2004

Kai C. Wollert, Medizinische Hochschule Hannover, Hannover
Klaus-Dieter Schlüter, Universität Giessen, Giessen

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Gap Junctions and Cell-Cell Communication in the Cardiovascular System
Published: 1 May 2004

Stefan Dhein, University of Leipzig, Leipzig
Habo Jongsma, Utrecht University, Utrecht
Jeffrey E. Saffitz, Washington University, St. Louis

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Mechanisms of Reperfusion Injury
Published: 15 Feb 2004

David García-Dorado, Hospital Universitari Vall d'Hebron, Barcelona
Lance Becker, University of Chicago, Chicago

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Infection and Inflammation in the Cardiovascular System
Published: 15 Oct 2003

Fiorella Calabrese, University of Padua Medical School, Padua
Allard C van der Wal, University of Amsterdam, Amsterdam
Marcel Levi, University of Amsterdam, Amsterdam

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Cell Transplantation and Stem Cells in the Cardiovascular System
Published: 1 May 2003

Marcel A.G. van der Heyden, University Medical Center Utrecht, Utrecht
Jürgen Hescheler, University of Cologne, Cologne
Christine L. Mummery, Netherlands Institute of Developmental Biology, Utrecht
Loren J. Field, Indiana University School of Medicine, Indianapolis

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Sodium and the Heart
Published: 15 Mar 2003

Burkert Pieske, University of Göttingen, Göttingen
Steven R Houser, Temple University School of Medicine, Philadelphia
Gerd Hasenfuss, University of Göttingen, Göttingen
Donald M Bers, Loyola University, Chicago

Click here to access the table of contents for this issue.