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Virtual Spotlight

Reducing the Impact of Myocardial Ischaemia/Reperfusion Injury

This online “virtual spotlight issue” addresses the recent advances in the pathophysiology of cell death and adverse ventricular remodelling secondary to myocardial ischaemia/reperfusion and the therapeutic approaches aimed at reducing or preventing it. Emerging concepts in cell death mechanisms and cardioprotection signalling are covered as well as the molecular basis of scar formation and evolution and changes in remote myocardium. Emphasis is placed on the analysis of the opportunities and obstacles for the translation of this knowledge to the treatment of patients with clinical situations involving transient myocardial ischaemia, from acute myocardial infarction to cardiac resuscitation and surgical coronary revascularization.

This collection of reviews and original articles on this theme will be continually refreshed so as to provide a living, up-to-date resource for those interested in the field.

Basic signalling mechanisms

Mitochondria-related mechanisms

Basic pharmacological approaches

Clinical Applications