Published on behalf of
Thomas F. Lüscher
Bernard J. Gersh
Coronary Heart Disease
Circulating microparticle levels in patients with coronary artery disease: a new indicator of vulnerability?
Eur. Heart J. (2011), 32 (16), 1958-1960; 10.1093/eurheartj/ehr055 - Click here to view abstract
Release of microparticles (MPs) into the blood stream following cell activation or apoptosis. MPs released from endothelial cells and/or platelets, characterized by phosphatidylserine exposure and presence of CD31 (CD31+ AnnV+ MPs) may serve as a pronostic marker for major adverse cardiovascular events. In addition, circulating MPs may contribute to the development of athero-thrombosis by promoting endothelial dysfunction, favouring intraplaque angiogenesis and thrombus formation.
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