Published on behalf of
Thomas F. Lüscher
Bernard J. Gersh
Coronary Heart Disease
Circulating microparticle levels in patients with coronary artery disease: a new indicator of vulnerability?
Eur. Heart J. (2011), 32 (16), 1958-1960; 10.1093/eurheartj/ehr055 - Click here to view abstract
Release of microparticles (MPs) into the blood stream following cell activation or apoptosis. MPs released from endothelial cells and/or platelets, characterized by phosphatidylserine exposure and presence of CD31 (CD31+ AnnV+ MPs) may serve as a pronostic marker for major adverse cardiovascular events. In addition, circulating MPs may contribute to the development of athero-thrombosis by promoting endothelial dysfunction, favouring intraplaque angiogenesis and thrombus formation.
Illustration of the reciprocal interaction between endothelial dysfunction, inflammation and the natural history of coronary artery disease. Blue arrows marked with the box ‘ED’ represent processes in which endothelial dysfunction modifies the evolution or prognosis of coronary artery disease. Red arrows represent ways in which coronary artery disease contributes to a worse endothelial function.
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