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Thomas F. Lüscher
Bernard J. Gersh
The controversial role of Lp-PLA2. The enzyme hydrolyses a number of mediators potentially involved in atherogenesis, such as oxidized low-density lipoproteins (oxLDL) and platelet-activating factor (PAF), thus reducing their negative impact. At the same time, products of Lp-PLA2-mediated degradation of these molecules may also have proinflammatory, proliferative, and ultimately proathergenic roles. Notably, Lp-PLA2 is itself hyperexpressedin the setting of inflammation, and it is inhibited by peroxynitrite (ONOO-). What causes this equlibrium to tip from a beneficial role for Lp-PLA2 to a proatherogenic role of the enzyme remains unknown.
Potential mechanisms of increased aortic stiffness and cardiovascular risk in people with post-traumatic stress disorder.
Most variations in regulatory and transcribed regions of DNA are weakly and inconsistently associated with variation in phenotypes such as risk of common complex diseases, plasma concentrations of lipoproteins, and the manner in which statins affect both, probably because we are still only beginning to understand how ∼80% of DNA regulates the way in which transcribed regions (‘genes’), in <2% of DNA, are turned on and off.
Mechanisms of action of the inhalation of particulate matter on cardiac functions and cardiovascular disease.
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