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Thomas F. Lüscher
Bernard J. Gersh
The controversial role of Lp-PLA2. The enzyme hydrolyses a number of mediators potentially involved in atherogenesis, such as oxidized low-density lipoproteins (oxLDL) and platelet-activating factor (PAF), thus reducing their negative impact. At the same time, products of Lp-PLA2-mediated degradation of these molecules may also have proinflammatory, proliferative, and ultimately proathergenic roles. Notably, Lp-PLA2 is itself hyperexpressedin the setting of inflammation, and it is inhibited by peroxynitrite (ONOO-). What causes this equlibrium to tip from a beneficial role for Lp-PLA2 to a proatherogenic role of the enzyme remains unknown.
Potential mechanisms of increased aortic stiffness and cardiovascular risk in people with post-traumatic stress disorder
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