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Lipoprotein-associated phospholipase A2, a marker of vascular inflammation and systemic vulnerability

Eur. Heart J. (2009), 30 (23), 2829-2831; 10.1093/eurheartj/ehp311 - Click here to view abstract

Lipoprotein-associated phospholipase A2, a marker of vascular inflammation and systemic vulnerability

The controversial role of Lp-PLA2. The enzyme hydrolyses a number of mediators potentially involved in atherogenesis, such as oxidized low-density lipoproteins (oxLDL) and platelet-activating factor (PAF), thus reducing their negative impact. At the same time, products of Lp-PLA2-mediated degradation of these molecules may also have proinflammatory, proliferative, and ultimately proathergenic roles. Notably, Lp-PLA2 is itself hyperexpressedin the setting of inflammation, and it is inhibited by peroxynitrite (ONOO-). What causes this equlibrium to tip from a beneficial role for Lp-PLA2 to a proatherogenic role of the enzyme remains unknown.

Post-traumatic stress disorder: breaking hearts

Eur. Heart J. (2011), 32 (6), 668-669; 10.1093/eurheartj/ehq404 - Click here to view abstract

Post-traumatic stress disorder: breaking hearts

Potential mechanisms of increased aortic stiffness and cardiovascular risk in people with post-traumatic stress disorder.

Genes and cardiovascular risk

Eur Heart J (2013) 34 (13): 949-950; 10.1093/eurheartj/ehs439 - Click here to view abstract

Genes and cardiovascular risk


Most variations in regulatory and transcribed regions of DNA are weakly and inconsistently associated with variation in phenotypes such as risk of common complex diseases, plasma concentrations of lipoproteins, and the manner in which statins affect both, probably because we are still only beginning to understand how ∼80% of DNA regulates the way in which transcribed regions (‘genes’), in <2% of DNA, are turned on and off.

Airborne pollution and cardiovascular disease: burden and causes of an epidemic

Eur Heart J (2013) 34 (17): 1251-1253; 10.1093/eurheartj/eht045 - Click here to view abstract

Airborne pollution and cardiovascular disease: burden and causes of an epidemic


Mechanisms of action of the inhalation of particulate matter on cardiac functions and cardiovascular disease.

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